Semi-quantitative cerebral blood flow parameters derived from non-invasive [15O]H2O PET studies

A Non-invasive Method for Quantifying Cerebral Blood Flow by Hybrid PET/MR.

While positron emission tomography (PET) with 15O-water is the gold standard for imaging cerebral blood flow (CBF), quantification requires measuring the arterial input function (AIF), which is an invasive and noisy procedure. To circumvent this problem, we propose a non-invasive PET/ magnetic resonance (MR) approach that eliminates the need to measure the AIF by using global CBF determined by ...

Evaluation of an automatic non-invasive quantitative measurement method of the regional cerebral blood flow

Cerebral blood flow with [15O]water PET studies using an image-derived input function and MR-defined carotid centerlines.

Full quantitative analysis of brain PET data requires knowledge of the arterial input function into the brain. Such data are normally acquired by arterial sampling with corrections for delay and dispersion to account for the distant sampling site. Several attempts have been made to extract an image-derived input function (IDIF) directly from the internal carotid arteries that supply the brain a...

Cerebral Blood Flow and Transit Time Measured by Quantitative Arterial Spin Labeling: Comparison with O-PET

Introduction Arterial spin labeling (ASL) is a unique MR imaging technique that allows for non-invasive measurement of cerebral blood flow (CBF). Recently, ASL with multiple delay time sampling has become available on clinical MR imagers. Quantitative signal targeting by alternating radiofrequency pulses labeling of arterial regions (QUASAR) is one of such techniques, and allows for quantitativ...

Whole blood viscosity parameters and cerebral blood flow.

This report describes the statistical relationship of several whole blood viscosity parameters and cerebral blood flow (CBF) in 53 consecutive patients and normal controls. Significant correlations were present between CBF and serum fibrinogen (P = .05), hematocrit (P less than .05), and a relationship involving both fibrinogen and hematocrit (P less than .01). We conclude that heightened whole...